Clinically, for whether it is insulin resistance, that is, whether the insulin dosage of the patient reaches or exceeds 2U/Kg as the standard. If the definition of insulin resistance is negatively met from the perspective of insulin dosage, it needs to be further analyzed whether there are causes of insulin resistance, generally common causes, such as ketoacidosis, severe infection, stress, severe anxiety, etc. Secondly, whether diet management and exercise management are regular, and thirdly, laboratory tests are needed to clarify whether insulin antibodies exist; also, insulin injection techniques and methods and the appropriateness of insulin preservation. For insulin resistance, high doses of insulin should be avoided as much as possible in the application of drugs. Appropriate application of metformin, α-glucosidase inhibitors, DPP-4 inhibitors, glitazone insulin sensitizers, and GLP-1 agonists can help reduce resistance and may increase insulin efficacy and reduce insulin dosage. The specific clinical application of one or two drugs needs to be combined with the patient’s body type, the type of elevated blood sugar, fasting, postprandial hyperglycemia or both, the patient’s dietary habits and the presence of diabetic complications and other lesions or metabolic abnormalities to adjust the dosage and program of medication. There is also a fundamental method, which is exercise therapy. Effective exercise therapy can help improve insulin resistance, especially for obese patients, and can play a significant role in improving insulin resistance. But the method must be appropriate, to avoid strenuous exercise, but also to avoid the injury caused by exercise.