Pimples are usually the common name for acne. Wet compresses with saline have no significant effect on acne and are often treated with retinoids and antibiotics. Acne is a disease caused by multiple factors, such as abnormal androgen levels and propagation of Propionibacterium acnes. Saline, a 0.9% sodium chloride solution, has no significant therapeutic effect on acne, although it can be used to irrigate wounds, clean the skin, and so on. The first-line topical medications for acne are retinoids, such as adapalene and tazarotene, which promote epithelial keratinocyte growth and stratum corneum shedding. Antibiotics such as fusidic acid, erythromycin, and lincomycin are bactericidal for Propionibacterium acnes and can also be used to treat acne, and in severe cases, oral doxycycline can be used. After suffering from acne, the specific medication should be based on the condition, guided by a professional doctor, do not self-abuse of drugs.