Diabetes is not a precursor of uremia, but only a part of patients with diabetic nephropathy, because of blood glucose, blood pressure factors are not controlled, further deterioration of renal function will lead to uremia, if necessary, dialysis treatment. Diabetic nephropathy combined with uremia is most common in patients with type 1 diabetes mellitus, which is the most serious microvascular complication in patients, and the most important life-threatening factor in type 1 diabetes mellitus. If diabetic patients with renal disease, must control blood glucose, especially diabetes combined with hypertension patients, as far as possible, choose ACEI class, ARB class of antihypertensive drug therapy to control blood pressure, to protect renal function, to reduce urinary protein, to slow down the progression of renal function or have a certain therapeutic effect.