When the anion gap is high, metabolic toxicity due to diabetic ketoacidosis, uremia, etc. is usually considered. Sodium bicarbonate is usually used to neutralize acids, and dialysis therapy may be indicated if the situation is severe, and dietary modifications are required. The anion gap is generally defined as the difference between the measured cation and unmeasured anion concentrations in plasma. The first step is to look for the cause and take targeted treatment. If it is due to diabetic ketoacidosis, insulin etc. should be used to control blood glucose and to avoid infection; if it is due to uremia, dialysis therapy and a light diet should be taken. Secondly, the degree of elevation should be considered. If the elevation is relatively small, oral sodium bicarbonate can be taken; if it is more serious metabolic acidosis, hemodialysis therapy is also needed to correct it. In short, on the one hand, according to the cause of the targeted treatment, on the other hand, need to pay attention to changing lifestyle habits. If the situation worsens, it is necessary to consult a doctor in time and hospitalization.