The causes of gastric distress at 1:00 a.m. usually include duodenal ulcer, duodenal bulbitis and reflux esophagitis, etc., which need to be treated as soon as they are detected. Because the gastrointestinal system is protected by the mucous membrane, so it is generally not attacked by gastric acid, but when the mucous membrane protective barrier is damaged, there will be mucosal ulcers or inflammation and other phenomena, due to the human body’s gastric acid is uninterrupted secretion, especially in the middle of the night when the gastric acid will be in the secretion of the peak, when the gastric acid is more prone to gastric lining caused by stimulation, triggering the symptoms of gastric discomfort. In addition, some patients with reflux esophagitis also have the phenomenon of stomach discomfort in the middle of the night, so it is best to raise the pillow when sleeping. Repeated nighttime stomach upset, it is recommended to timely hospital treatment, under the guidance of the doctor standardized diagnosis and treatment.