Bronchitis, coughing and spitting up white sputum in the middle of the night is due to excessive inflammatory secretions in the airways, which irritate the airways, thus causing bouts of coughing and expectoration of sputum during sleep. Trachea-bronchitis is an inflammation of the mucous membrane of the trachea-bronchial tubes caused by biological, physical and chemical stimuli or allergies, which is mainly manifested by coughing and sputum. Tracheobronchial mucosa in the inflammatory state of congestion, edema, secretion increase, when the secretion gathered into the amount, can stimulate the airway to cause paroxysmal cough and discharge secretion, so the performance of the middle of the night cough, spit white sputum. Tracheo-bronchitis, such as heavy cough, sputum volume can be used Ambroxol, bromhexine, etc. to relieve cough and resolve sputum. Spitting white sputum suggests that tracheobronchitis is not based on bacterial infection and does not require antibiotic treatment. Cough and white sputum can be caused by a variety of diseases, if the symptoms are not relieved or worsened, please go to the hospital for further examination and treatment to avoid delay.