Estrogen supplementation is not recommended for normal women and should be used under medical supervision if the condition requires it. Women can raise estrogen by taking estradiol valerate, conjugated estrogens, and nilestrol. Estrogen is a sex hormone that can stimulate the proliferation and hypertrophy of uterine myoblasts, promote endometrial hyperplasia, increase the secretion of cervical mucus, promote the hyperplasia of mammary gland ducts, and cause the labia to develop, plump up, and deepen in pigmentation, among other effects. Estrogen can be used to treat amenorrhea, premature ovarian failure, and menopausal syndrome. Its adverse reactions include headache, edema, hyperpigmentation and leukorrhea. Contraindications are hypersensitivity, known or suspected pregnancy, history of arteriovenous thrombosis, etc. Estrogen must be used under the guidance of a doctor, do not stop the drug and adjust the dosage by yourself, and consult a doctor in time if you feel unwell.