The number of times of chemotherapy for colon cancer should be decided according to the choice of specific treatment methods, which may range from 2 to 12 times. Colon cancer is a malignant tumor caused by heredity, bad dietary habits and other factors, and one of the main treatments after diagnosis is chemotherapy, which may include preoperative neoadjuvant chemotherapy, postoperative adjuvant chemotherapy and palliative chemotherapy. The specific number of chemotherapy treatments may vary with different therapies. Preoperative neoadjuvant chemotherapy aims to improve the success rate of surgical resection, and generally needs to be carried out 2~4 times; postoperative adjuvant chemotherapy aims to timely eliminate the residual lesions that have not been resected by surgery, so as to improve the prognosis, and the number of times is 6~8 times; palliative chemotherapy is commonly used in patients with advanced colon cancer, and it is often carried out for about 12 times. Patients can actively cooperate with doctors for treatment.