Primary hand sweating is an autonomic dysfunctional disorder. Because of involuntary sweating, which is especially severe when nervous or when interacting with strangers, patients often refuse to shake hands with others, seriously affecting their social activities and interactions with the opposite sex, creating a sense of inferiority, anxiety and fear of social activities, and mental depression, so most patients have various aspects of psychological disorders . A significant proportion of patients experience long-term side effects such as compensatory excessive sweating of the trunk, excessively dry palms, and still slightly moist after surgery, which also seriously affect the quality of life of patients after surgery. Thoracic sympathetic nerve chain dissection is the current standard of care for primary hand sweating. Compensatory hyperhidrosis is a common postoperative complication. A single-site T3 or T4 sympathetic nerve chain dissection is considered to be the more desirable procedure to effectively treat hand sweating and significantly reduce postoperative complications. The impact of hand sweating on the patient’s quality of life is manifested in several areas, including physiological function, physical function, emotional function, and mental health. Thoracic sympathetic nerve chain dissection is safe, efficacious, and can significantly improve the quality of life and mental health status of patients with hand sweating.