Monkeypox can appear on the face and extremities and can also involve the oral mucosa, digestive tract, genitals, conjunctiva and cornea. Monkeypox virus is a double-stranded DNA virus belonging to the genus Poxvirus in the family Poxviridae, which is similar to smallpox virus and causes a similar rash with similar clinical symptoms. First, the monkeypox rash usually begins to appear within 1 to 5 days after the onset of fever. It usually appears on the face first, and then gradually spreads to the limbs and other parts of the body in a centrifugal distribution, and the rash can appear on the palms of the hands and feet, and the number of rashes ranges from a few to thousands. In addition to this, the rash can also appear in the oral mucosa, digestive tract, genitals, conjunctiva and cornea, etc. The rash can go through several stages of transformation, for example, the common sequence is macular rash → papule → herpes → pustule → scab, and different phases of the rash may also appear at the same time. Due to the high number of monkeypox rashes, it is a great health hazard for young children and immunocompromised people, therefore, once the related clinical symptoms appear, it is necessary to consult a doctor in time for observation and treatment to avoid serious health damage.