The cause of localized skin tightening is unknown and is thought to be related to genetics, infection, immune dysregulation, connective tissue metabolism and vascular abnormalities. The localized form has no visceral damage and has a good prognosis. The systemic type can be associated with multiple organ damage, with insidious onset and slow disease progression, often extending over several years or even decades, together with esophageal and gastrointestinal damage, lung, heart and kidney can be involved, and finally most end up with nutritional disorders, failure of all vital organs and complications. Although there are many treatment methods, but the effect is not the same, but the drug can reduce the symptoms and delay the progress of the disease. Our country uses a combination of Chinese and Western medicine, reasonable and symptomatic choice of drugs, strengthen the confidence of patients, adhere to the medication with when there will be better results. Local skin tightening disease care: 1, psychologically: should be fully aware of scleroderma is one of the poor response to treatment, with long-term, recurrent, uncertain prognosis and efficacy characteristics, often affecting daily life, so that the appearance of change, the disease is difficult to heal, resulting in anxious to treat, but also fear the contradictory psychology of poor treatment, should have a correct understanding of the disease, set up the disease to overcome They should have a correct understanding of the disease, establish confidence in overcoming the disease, and be willing to accept treatment and care. Strictly grasp the time of oral medication and the exact dose, and strictly adhere to the medication under the guidance of the doctor. 2, in the diet: some scleroderma patients have difficulty in swallowing solid food, and often choke when eating carelessly, more intermittent, lying position aggravated with posterior sternal pain. Therefore, these patients need strict dietary management; should be high protein, high vitamin fluid diet, eat more fresh fruit juice, vegetables, avoid eating spicy and irritating food. When eating, take a 20-degree tilt position with head high and feet low to reduce gastric-esophageal reflux, and apply anti-reflux medication if necessary. If the swallowing difficulty is serious, give nasal fluid or/and intravenous nutrition to ensure the basic energy supply.