Lactulose is primarily indicated for the treatment of chronic constipation, as well as for the lowering of blood ammonia and the treatment and prevention of hepatic coma or precoma. Major contraindications include the development of galactosemia, concomitant use with other laxative agents, and hypersensitivity to lactulose and its components. Adverse reactions include bloating, abdominal pain, diarrhea, and electrolyte disturbances. The generic name of morpholine is domperidone, which is a gastric stimulant and is mainly indicated for symptoms such as dyspepsia, belching, and abdominal distension. Contraindications for domperidone include allergy to the drug; diseases such as pheochromocytoma, breast cancer, mechanical intestinal obstruction, gastrointestinal bleeding; increase gastric power may be dangerous, such as gastrointestinal bleeding; prolactin-secreting pituitary tumors; moderate to severe hepatic insufficiency. Adverse reactions include headache, insomnia, increased prolactin, abdominal cramps, diarrhea, nausea, heartburn, and rash. There is no contradiction between the two drugs in terms of indications, contraindications and mechanism of action, so they can be used together. The specific use of medication is recommended to consult a professional doctor, do not unauthorized use of drugs.