Acute gastritis, costochondritis, and pericarditis are the common clinical causes of pressure pain in the fossa of the heart. 1. Acute gastritis: the gastric mucosa of people suffering from this disease will be edematous and congested, and when pressing on the heart socket area, it will cause pressure on the stomach, and gastric acid and other gastric contents will stimulate the stomach wall, resulting in pain at the point of pressing. 2. Costochondritis: this disease refers to the inflammatory reaction of the cartilage at the junction of the sternum and the ribs, which is clinically manifested as the enlargement of single or multiple costal cartilages accompanied by localized pain and pressure. 3. Pericarditis: People suffering from this disease, the inflammatory exudation formed in the pericardium’s dirty layer and wall layer will cause stimulation to the peripheral nerves, thus causing pain in the precordial area and the back of the sternum, which will be aggravated by pressing on the area of the heart’s fossa, coughing, and taking a deep breath. There are many causes of pain when pressing on the cardiac fossa, so it is recommended that people with the disease should go to the hospital for medical examination and treatment according to the doctor’s instructions.