Epilepsy is a highly prevalent disease, with nearly 10 million people living with epilepsy in China, a number that will continue to grow. In a seizure, the patient suddenly loses consciousness, falls to the ground and convulses, which can be accompanied by foaming at the mouth and screaming, which is a serious threat to the patient’s life. In life, when it comes to grand mal seizures, many people do not know what to do, and if they do, it will help the patient. So what do you do when you have a seizure? Some patients in grand mal seizures first scream, then lose consciousness and fall, the whole body muscle rigidity, the head can be deviated to the side, a few seconds later there are clonic convulsions, convulsions gradually aggravated, foaming at the mouth such as tongue was bitten to appear blood foam, some patients have urinary and fecal incontinence phenomenon, tens of seconds. After the convulsions, the whole body relaxes or enters drowsiness (lethargic phase), after which consciousness slowly returns. When a seizure aura is detected, quickly let the patient lie flat on the bed or lie down on a flat place nearby; when the patient is found to fall to the ground, quickly hold the patient and let him or her fall down with the posture to prevent sudden fall and injury to the head and other parts of the body. Remove anything hard or dangerous on the body, put a soft thing under the head, untie the collar, cuffs, belt, and remove dentures if there are any, so that the airway is clear. It is not necessary to call or press the patient desperately to keep him from twitching, because no matter how hard you use at this time, it will not help and will not shorten the time of his convulsions. The patient’s head and body should be turned to the side to make the secretions flow out naturally. Once the seizure starts, do not put anything between the upper and lower teeth, especially hard things, or you will break your teeth. It is best to place a gauze tongue depressor between the patient’s upper and lower molars before the onset of the aura, to prevent the patient from biting his or her tongue during the clonic phase. Although the patient may sometimes bite through the tongue and spit out blood, it is usually mild and can heal on its own. Patients with epilepsy need to be treated promptly and take medication as prescribed, or in severe cases, treated with epileptic focal resection or vagus nerve electrical stimulation, in order to effectively reduce seizures and harm.