Seronegative spondyloarthritis treatment includes life care such as attention to rest, medication such as celecoxib, etc. It is a common clinical class of chronic inflammatory rheumatic diseases, the specific treatment should be carried out under the guidance of a doctor. 1. Life care: this kind of disease need to pay more attention to rest, and to ensure adequate physical exercise, because physical exercise can strengthen the strength of the muscles of the lower back, so as to reduce the sense of pain. 2. Drug therapy: For patients with severe symptoms of seronegative spondyloarthritis, relevant drug therapy should be carried out under the guidance of doctors, such as non-steroidal anti-inflammatory and analgesic drugs, including celecoxib capsules, nimesulide dispersible tablets, etc., glucocorticosteroids, including prednisone acetate, etc., and anti-rheumatic drugs, including methotrexate, thalidomide, leflunomide and so on. Patients with extremely severe seronegative spondyloarthritis and severe deformity will need to be corrected by surgery. Patients are advised to visit the hospital in time for treatment under medical supervision.