Difficulty seeing clearly when driving at night is usually caused by the following: First, it is caused by retinitis pigmentosa, a genetic disease that can lead to loss of function of a large number of retinal optic rod cells, resulting in poor dark vision. Second, due to optic rod cell dystrophy, which is also a disease caused by a genetic abnormality that can cause significant night blindness. Third, due to advanced glaucoma, prolonged high intraocular pressure can cause the patient’s optic nerve to atrophy, resulting in reduced visual field with night blindness. Fourth, caused by vitamin A deficiency night blindness, which is common in patients with malnutrition and long-term eccentricity. Vitamin A is an important element that provides nutrients to the retina, and once deficient, it can lead to significant night blindness. Fifth, caused by myopia or astigmatism, when the pupil is further dilated in the dark environment at night, it will increase the effect of myopia and astigmatism on vision, thus making it difficult to see clearly.