Pus-filled acne is usually moderate acne, boils or carbuncles, etc. Most of them need to be treated with a combination of topical and oral medications, and some of them also need physical therapy or even surgery. 1. Moderate acne: Moderate acne often manifests itself in the form of lesions such as inflammatory papules and pustules, which can be treated with topical application of adapalene gel and tazarotene gel, along with antibiotic ointments such as fusidic acid cream and mupirocin ointment. This condition also requires oral antibiotic medication and retinoid medication, such as doxycycline, minocycline, and isotretinoin. 2. Boils or carbuncles: Multiple hair follicles infected with Staphylococcus aureus at the same time will lead to nodules with pus in the center of the nodules, which can be discharged on their own and then gradually healed. A small number of them can not be self-healing, this situation needs to be treated with medication, such as topical mupirocin ointment, clindamycin ointment, oral amoxicillin capsules, and so on, and even have to be incised to drain the pus. For the more serious can be combined with infrared rays, ultra-short wave and other physical methods of treatment. Acne pus should be as soon as possible after the medical treatment, according to the specific situation to take the appropriate treatment, do not casually treatment, to avoid leading to adverse consequences. The above drugs need to be used in accordance with medical advice.