If diabetic patients have diarrhea symptoms, the treatment is divided into several aspects: First, the most important thing is to control blood sugar, to relieve the effect of high blood sugar on the intestinal nerve function, no matter oral hypoglycemic drugs or application of insulin, the purpose is to control the blood sugar at the ideal level. Second, the use of nutritive drugs, including methylcobalamin, Epalrestat, lipoic acid and so on. Third, use drugs to improve microcirculation such as Nicorandil. Fourth, the use of drugs to improve intestinal flora to relieve the patient’s own intestinal flora disorders. Fifth, if necessary, antibacterial drugs can be used, such as quinolone antibacterial drugs are recommended, because this patient is prone to intestinal infections, the use of levofloxacin, ciprofloxacin and other quinolones can achieve the purpose of treatment of intestinal infections. It is only when these treatments are combined together that the patient’s diarrhea symptoms can be controlled.