Ketone bodies +- need to be decided according to the patient’s condition, if there is no diabetes and the ketone bodies in the urine appear plus or minus sign, ask the patient whether there is a recent history of weight loss and dieting, which may be caused by starvation ketosis. If the patient has diabetes mellitus, ketone body +- is an acute complication of diabetes mellitus, according to the patient’s current condition and the measurement of blood glucose, such as there is no nausea, vomiting, fever, infections, the presence of stress state to decide whether ketone body +- need special treatment. If the patient’s condition is relatively good, and there is no nausea, vomiting and other gastrointestinal reactions, the patient can be instructed to drink more water, and then to promote urination, ketone bodies +- can usually turn negative. If the patient’s condition is not good, it is necessary to actively give appropriate intervention to avoid further aggravation of ketone bodies and further aggravation of acute complications of diabetes. The prerequisite for this is good glycemic control.