Infectious and non-infectious factors may be considered in the presence of elevated total complement levels. 1. Infectious factors: Increased total complement level is mainly considered as an infectious factor, such as the presence of bacterial infections, viral infections, fungal infections, mycoplasma, chlamydia infections, etc. can lead to an increase in the presence of prostaglandins, tumor necrosis factor, which can also lead to an increase in the total complement level. 2. Non-infectious factors: when there are non-infectious factors such as autoimmune diseases, rheumatoid arthritis, dry syndrome, systemic lupus erythematosus, etc., tissue damage, some malignant tumors can also lead to the problem of elevated total complement. Therefore, if the total complement is found to be elevated, it is recommended to consult the relevant departments of regular hospitals, and the diagnosis should be confirmed by combining clinical symptoms with other tests.