Sacubitril valsartan sodium tablets have some degree of antihypertensive effect, the specific efficacy varies from person to person. Sacubitril valsartan sodium tablets is a kind of compound preparation, the main ingredients include sacubitril and valsartan, suitable for the treatment of hypertension or the American New York Heart Association (NYHA) class II to IV, left ventricular ejection fraction ≤ 40% of the adult chronic heart failure patients. Adverse effects of the drug include hypotension, angioedema, renal impairment, and hyperkalemia. The drug has a certain antihypertensive effect, but the individual using the drug has variability, resulting in different effects of the drug, so the specific antihypertensive effect varies from person to person. Contraindications to the drug include hypersensitivity to the product, patients with hereditary or idiopathic angioedema, patients with a history of angioedema associated with angiotensin-converting enzyme inhibitor or angiotensin II receptor antagonist therapy, cholestasis and biliary cirrhosis, severe impairment of hepatic function, and mid- and late-term pregnancy. Specific medication should be administered under the guidance of a specialist, and should not be used without authorization to avoid serious adverse reactions.