Scrotal nodules may be caused by scabies and folliculitis. 1. Scabies: the disease is caused by scabies infection, easy to occur in the folds of the skin, growing in the groin and scrotum area of scabies, mostly appear as red nodules. The nodules are probably smooth, soybean-sized and red, accompanied by itching, which is worse at night. 2. Folliculitis: because the patient did not pay attention to the perineum cleanliness and hygiene, resulting in local hair follicle blockage and breeding bacteria, resulting in inflammation and infection. The nodule will have obvious pain when touching, and there is redness and swelling around it. In addition, patients with varicocele may also have nodules inside the scrotum due to the accumulation of varicose veins inside the scrotum. It is recommended that patients with scrotal nodules go to the hospital to find out the cause of the problem.