A large pimple on the nose may be caused by folliculitis and acne, and it is recommended that patients use medication according to the specific symptoms under the guidance of a doctor. 1. Folliculitis: It is caused by limited purulent inflammation of the hair follicles in the nose. Patients can use topical antibiotic drugs, such as mupirocin ointment, fusidic acid ointment for treatment. At the same time, pay attention to the cleanliness of the local lesions. 2. Acne: For patients with acne on the nose, you can use topical adapalene gel, fusidic acid cream, benzoyl peroxide, etc., and in severe cases, you can take oral isotretinoin, doxycycline and other drugs. For patients with a big pimple on the nose, it is recommended to go to the regular hospital in time for examination, standardized treatment under the guidance of a professional doctor, and not blindly use medication on their own.