The cause of eyelid swelling in the morning needs to be judged according to different situations, if it is unilateral eyelid swelling may be inflammation, allergy, or eye lesions, mosquito bites, which can be judged from the appearance of the eyelid, if it is bilateral eyelid swelling, it may be bilateral eye lesions or allergies to certain drugs and cosmetics. Excluding this situation, it is the systemic lesions caused by bilateral eyelid swelling, the most common are heart disease, kidney disease, rheumatic system disease, thyroid disease and liver disease. Heart disease is often accompanied by symptoms of heart failure, such as inability to lie down at night or palpitations after activity, and can be associated with arrhythmias, which can be differentiated by electrocardiogram and cardiac ultrasound. In addition to bilateral swelling of the eyelids in the morning, kidney disease can have increased foam in the urine, which does not disappear within a short period of time and can be suggested by appropriate urine and blood tests. In the case of liver disease, often with a history of hepatitis or ascites, jaundice can occur in the corresponding areas suggesting liver abnormalities. If it is a rheumatic disease, the most common is systemic lupus erythematosus, can appear bilateral eyelid edema, but often accompanied by alopecia, facial rash and oral ulcers, blood immunological indicators can suggest the corresponding information, while other systemic diseases have the characteristics of the respective systemic diseases, which is conducive to the differential diagnosis in the clinic.