Bleeding in advanced stage of oral cancer may be caused by invasion of cancer tissues into blood vessels, which may cause anemia or even endanger life in serious cases, so it is recommended to actively cooperate with doctor for treatment. In the late stage of oral cancer, the cancer grows rapidly and may infiltrate and grow into the surrounding tissues, when it cleans the well-known arterial and venous blood vessels, it may cause more than bleeding, and if not treated in time, it may cause excessive blood loss and lead to shock, so carotid artery ligation can be considered in general. In addition, oral cancer can be manifested in the mouth as having deep and big ulcers, with necrotic depression in the center of ulcers, infiltrating tissues downward at the base, which can have the phenomenon of continuous blood seepage, and long-term blood seepage can cause hemorrhagic anemia. Radiotherapy and chemotherapy are needed to control the growth of tumor. For bleeding in mouth in advanced stage of oral cancer, it is suggested not to panic and go to hospital as soon as possible to cooperate with doctors for active treatment to control the development of the disease.