In the early stage of some common kidney diseases, such as chronic glomerulonephritis, hypertensive kidney injury, IgA nephropathy, there are no obvious clinical symptoms, when there are nausea, vomiting, weakness, poor nausea, itchy skin and other clinical not symptoms, often to the middle and late stage, or even the uremic phase. Therefore, early diagnosis of kidney disease, annual physical examination is very important, as well as in the presence of increased urinary foam, swollen eyelids, elevated blood pressure, etc., need to be alert to kidney-related diseases, timely hospital examination of urinary routine, creatinine, urea and other indicators, early diagnosis, early treatment and improved prognosis. In the early stage of kidney disease, often urine routine appears abnormal, earlier than the changes of creatinine and urea, the most important indicator is urine protein, which is closely related to the severity and prognosis of kidney disease, and requires active treatment to prevent kidney damage.