Children with precocious puberty are likely to have premature bone age and premature epiphyseal closure before they reach their developmental age, resulting in their generally shorter size in adulthood. Epiphyses are the secondary ossification centers that appear at different times after birth. Epiphyses and epiphyseal plates are the growth areas of immature long bones of the limbs, and they are also the weakest and most fracture-prone parts of the child’s skeleton. Need and the following symptoms to distinguish each other: long bone epiphyseal epiphyseal calcification insufficiency: cartilage ectodermal dysplasia syndrome is also known as Ellis-vanCreveld congenital malformation syndrome, congenital chondrocalcification disorders of heart disease syndrome, cartilage ectodermal dysplasia syndrome, etc. Health search, for autosomal recessive hereditary disease? The disease is characterized by short-limbed dwarfism, congenital heart disease and mental retardation. In the case of short-limbed pygmies, there are short and thick limb bones, small distal fingers and toes, poorly developed hair and teeth, and incomplete calcification of the epiphyses of the long bones of the whole body. General X-ray can confirm whether the epiphyses close prematurely. Diagnostic examination of precocious puberty: detailed and complete medical history, including the development of sexual characteristics, vaginal bleeding, and the use of endocrine drugs. Radioimmunoassay to measure follicle stimulating hormone FSH and LH can help to differentiate between true and pseudo precocious puberty. In somatic precocious puberty, there may be enlarged ovaries and cystic changes. Retroperitoneal insufflation angiography may be performed when adrenocortical disorders are suspected. Frontal and lateral images of the skull, observe the size of the pterian saddle in order to exclude tumors. 1, plasma FSH, LH determination idiopathic precocious puberty children plasma FSH, LH basal value can be higher than normal, often not easy to judge, with the help of GnRH stimulation test, also known as luteinizing hormone releasing hormone (LHRH) stimulation test. Generally use intravenous injection of Gnrh, according to 2.5μg/kg/maximum dose ≤ 100μg), before the injection (basal value) and 30, 60, 90 and 120 minutes after the injection were taken to determine the serum LH and FSH, when the HL peak value > 15U / L (female), or > 25U / L (male); LH / FSH peak value > 0.7, LH peak / basal value > 3, it can be It is considered that its gonadal axis function has been activated. Bone age is assessed according to the X-ray film of hand and wrist, and whether the skeletal development of the disk tons is ahead of schedule, and children with precocious puberty usually have a bone age exceeding the actual age. 3, ultrasound Choose pelvic ultrasound to check the development of ovaries and uterus in girls; pay attention to the testes and adrenal cortex in boys; if pelvic ultrasound shows that multiple follicles ≥4mm can be seen in the ovaries, then precocious puberty; if a single follicle with a diameter of >9mm is found, then it is mostly cysts; if the ovaries are not large and the length of the uterus is >3.5cm, and the endothelium is seen to thicken, then it is mostly the role of exogenous androgens. CT or MRI examination If intracranial tumor or adrenal disease is suspected, CT or MRI examination of the skull or abdomen should be performed. Other tests can be further selected according to the clinical manifestations of the children.