Acne refers to acne in medical terms. Trimethoprim cream is generally not used to get rid of acne, and its pharmacological action cannot eliminate acne. Patients who want to get rid of acne can use topical retinoids, such as isotretinoin and adapalene gel. Trimethoprim cream belongs to a compound preparation, which can be used externally to provide anti-inflammatory, anti-allergic, anti-itching and anti-fungal effects, but this drug has no specific efficacy in eliminating acne. For patients who have the need to get rid of acne, they can use topical retinoids, such as isotretinoin and adapalene, under the guidance of a doctor. Its pharmacological effect is to improve the keratinization of sebaceous gland ducts, promote sebum discharge, while inhibiting the activity of sebaceous glands, thus reducing sebum secretion, and inhibit the growth of Propionibacterium acnes, which can play a role in eliminating acne. It is recommended that patients who need to get rid of acne, combined with their own situation, under the guidance of the doctor to take medication. Some patients may experience adverse reactions such as burning skin sensation, itching and pins and needles sensation when using Trimethoprim Cream, if you are allergic to the product, the drug is prohibited.