Compound betamethasone is a hormonal drug, whether in injectable or topical form, and long-term application can cause adverse effects of hormonal drugs, including sodium retention, potassium loss, electrolyte disturbances, congestive heart failure, hypertension, muscle weakness, aseptic necrosis of the femoral head, joint instability, and muscle weakness. It can also cause pancreatitis, abdominal distension, ulcerative esophagitis, peptic ulcer, and especially in dermatology it can affect skin wound healing, skin atrophy, bruises, bruises, facial erythema, urticaria, etc. It can also cause insomnia, depression, menstrual disorders, glaucoma, cataract, increased intraocular pressure, decreased blood pressure, shock-like reactions, etc. Therefore, it must be applied rationally in clinical practice.