High bilirubin is categorized into physiological and pathological, and should be treated according to the cause. 1. Physiological factors: Bilirubin production is greater than bilirubin excretion at birth in human beings, so bilirubin is elevated for a short period of time, which usually subsides after 1-2 weeks and does not require special treatment. 2. Pathologic factors: (1) Excessive bilirubin production due to the destruction of excessive red blood cells and increased intestinal – hepatic circulation, so that bilirubin increases, such as hemolytic jaundice, can be treated with prednisone acetate tablets, dexamethasone tablets and other medications, you should consult hematology in a timely manner, and under the guidance of the doctor active treatment. (2) Hepatic bilirubin metabolism disorders due to the low function of hepatocyte uptake and binding of bilirubin, so that the serum unconjugated bilirubin is elevated, such as heart failure caused by hypoxia, active diuretic (furosemide, spironolactone diuretic), expanding the coronary (isosorbide mononitrate) and other treatments for heart failure, or certain drugs, such as sulfanilamide, salicylates, mauroflorine glycoside C, etc, to reduce the use of this class of drugs. (3) Bile excretion disorder hepatocyte excretion of bound bilirubin obstacle or bile duct obstruction, can cause high bound bilirubinemia, if at the same time there is impaired function of hepatocytes, can also be accompanied by unconjugated bilirubin increase, common in hepatitis, intrahepatic or extrahepatic bile duct obstruction (stones, tumors, etc.), can be given to the antiviral (such as entecavir dispersible tablets), surgical stone obstruction and other treatments. If the phenomenon of high bilirubin, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease, to treat the cause, and to use medication under the guidance of the doctor, to avoid self-medication, which will lead to a misunderstanding of the condition.