Generally speaking, there is no one better drug, epprazole enteric-coated tablets or omeprazole, but each of them has different and more applicable diseases. Epprazole is mainly used for patients with reflux esophagitis and duodenal ulcer, and is contraindicated for those who are allergic to this drug. May appear diarrhea, dizziness and headache and other adverse reactions, taking the drug should pay attention to long-term use, and should be ruled out stomach and esophagus of other lesions, so as not to cover up the condition of delayed diagnosis and treatment. Omeprazole is mainly used for duodenal ulcer, gastric ulcer, upper gastrointestinal bleeding and reflux esophagitis, may appear dry mouth, abdominal distension, abdominal pain and other adverse reactions, the use of the drug should be noted that long-term application of this drug may lead to vitamin B12 deficiency or the occurrence of gastric carcinoid. It is contraindicated for those who are allergic to omeprazole and those with severe renal insufficiency. But Omeprazole has a wider range of indications. Therefore, which of the two types of drugs is better, according to the condition, under the guidance of the doctor to choose to use the drug, avoid self-medication.