Problems to be noted in taking medication for epilepsy patients

  Epilepsy, as a common disease of the central nervous system, currently affects about 8 million people in China. Although the latest medical development has resulted in many new technologies and methods for treating epilepsy, taking medication is still the main treatment for patients with epilepsy, and patients need to control their seizures by taking long-term medication. However, in epilepsy clinics, we found that many epilepsy patients and their families have misconceptions about epilepsy medication, leading to irregularities in medication treatment. The main problems and precautions in the treatment of epilepsy are described as follows: 1) excessive superstition in “ancestral recipes”, long-term use of proprietary Chinese medicines of unknown composition or so-called “ancestral recipes”.  Epilepsy is a very old disease that was recorded in the Yellow Emperor’s Classic of Internal Medicine 3000 years ago, which means that our ancestors have been studying this disease for a long time and have been exploring the treatment of this disease since ancient times. It is undeniable that there are many ways to treat epilepsy and epilepsy in traditional Chinese medicine, such as herbal medicine or acupuncture, but due to the lack of a verification system similar to modern medicine, the 19-year-old female epileptic patient, who was originally lively and cheerful, was able to reduce the number of seizures after taking the so-called “epileptic ning” Chinese medicine for 6 months. The number of seizures decreased, but she gradually developed symptoms such as dizziness, unstable walking, unresponsiveness, malaise, etc. After coming to the epilepsy clinic, we found when testing the serum drug concentration that the patient’s blood also contained phenytoin sodium, carbamazepine and other drugs, and the concentration of phenytoin sodium had exceeded the therapeutic concentration by more than 4 times. The above-mentioned manifestations of this patient were essentially caused by phenytoin sodium poisoning.  The patient’s family members were too worried and afraid of the side effects of the drugs. Many patients and their families are too worried and fearful about taking anti-epileptic drugs, thinking that the side effects of these drugs are too great and will lead to liver and kidney function damage and even mental retardation, thus refusing to take medication. It is undeniable that anti-epileptic drugs have different degrees of toxic side effects, but as long as patients use these drugs scientifically and correctly under the guidance of a specialist, the side effects can be well controlled and resolved. In fact, after the seizures are controlled with medication, the patient’s intelligence and quality of life will be significantly improved. On the contrary, if you do not use medication and have seizures, it will aggravate the patient’s condition and lead to a decrease in intelligence level, making the patient lose the ability to work and live.  3, the correct choice of drugs, not what drugs are effective for you: doctors generally have to choose the appropriate treatment drugs according to what the type of epilepsy is, which is very important. Patients with generalized or focal epilepsy are different in terms of medication use, otherwise it can be counterproductive. The patient and family members must go to a neurologist or epilepsy specialist at a regular hospital before deciding on medication, so that the doctor can decide on the type of medication to be used.  The first thing you need to do is to start increasing the dose of the drug slowly: many patients are so eager to control their seizures that they start taking the drug in too large a dose or increase the dose of the drug too quickly, leading to an increased incidence of side effects. The initial dose of drugs such as phenytoin sodium, carbamazepine, dutasteride, lamotrigine, etc. should be started from a small dose, and the dose should not be increased too quickly.  5, unauthorized discontinuation of drugs more patients: many patients do not know enough about the long-term, regular and systematic nature of drug therapy, patients stop taking drugs at will once the seizures are controlled, or reduce the dose, which leads to the aggravation of seizures, and even become epileptic persistent status, endangering life. There are strict indications for stopping medication in epilepsy patients: only after 3-5 years of complete seizure control and basic normalization of the EEG, it is possible to gradually stop the medication under the guidance of the doctor, and the discontinuation should be slow, and the process of reducing the medication should be at least half a year. However, there are many patients, especially those with symptomatic epilepsy, who may need long-term medication treatment and are not suitable for medication discontinuation.  For example, we have seen a case in which a pregnant woman discontinued her medication after finding out she was pregnant because she was worried that the medication would cause fetal malformation, thus causing the seizures to worsen and the seizure frequency to increase, resulting in intrauterine hypoxic asphyxia of the fetus, which instead led to the occurrence of stillbirth and abortion. There are also a few patients who unilaterally pursue complete control and increase the dose of drugs without authorization, resulting in drug toxicity.  6, many patients take a variety of drugs for treatment at the beginning of treatment. These patients believe that the more drugs they take, the better the treatment effect. In fact, for patients with first-time epilepsy, monotherapy is the correct and preferred method. The advantages of monotherapy are small side effects, good patient compliance, and no drug interactions. The advantages of monotherapy are fewer side effects, better patient compliance, and no drug-drug interactions. Only if multiple single-drug treatments are ineffective, can other drugs be added in combination.  For example, the author met a patient who was taking six kinds of anti-epileptic drugs at the same time, which resulted in the patient’s dullness, general swelling and aggravation of seizures.  The actual fact is that you will be able to get rid of the problem. The actual fact is that there is no cure for epilepsy, only drugs to control the seizures, any propaganda can cure epilepsy reports and advertising is bound to be a fraud, do not believe, otherwise it will only be a labor of life and injury.  The actual fact is that there are many patients who change their medication frequently. In fact, some drugs may require a period of time to reach a steady-state concentration before they can function, so you should not change drugs at will before then; some patients just change drugs because of some tolerable, transient adverse reactions.  The doctor advises that if an antiepileptic drug is effective, you should not switch to another drug at will, and you should not take it only for a short period of time after each seizure or intermittently, as this is an ineffective treatment.  The last thing to point out is that many patients are not very conscious of their follow-up. Because epilepsy is a seizure disorder, patients usually do not go to the hospital for regular follow-ups and examinations when they are not having seizures, but take their medications for a long time according to their initial physician’s orders, without regular examinations. The disadvantages of this are: possible liver and kidney damage caused by medication cannot be detected in time; the exact efficacy of medication cannot be properly evaluated; and possible changes in seizure type cannot be detected in time.