The cause of swelling of hands and feet in mid and late pregnancy is mainly due to the fact that the endocrine hormone level of pregnant women at this time has been relatively high, including estrogen and the elevation of saline corticosteroid and desoxycorticosterone in the late stages of pregnancy, which have obvious effects of water and sodium retention. Therefore, under the action of hormones pregnant women’s soft tissues will have more water residue, at the same time cause the plasma’s colloid osmotic pressure is reduced, so that the intertissue fluid and cellular fluid increase, the hands and feet swelling. In addition, with the development of the fetus, in late pregnancy, the weight of the fetus as well as the volume will gradually increase, which will be the inferior vena cava vein and other blood vessels produce extrusion, the blood supply of the lower limbs and water reflux is not good, thus aggravating the production of lower limb edema. The swelling of pregnant women in the late stage has gravity distribution, mainly in the lower limbs, bedridden for a long time can appear lumbosacral edema. Therefore, pregnant women in the middle and late should be appropriate exercise, sleep at night can be feet cushion high, at the same time to pay attention to routine urination or blood pressure monitoring, to prevent due to pregnancy in the middle and late hyperemesis leading to renal function damage, which further aggravate the edema.