In liver metastases or liver disease from cancer, serum alkaline phosphatase may be progressively increased, often exceeding 20 gold A units, and γ-glutamyl transpeptidase (γ-GT) may be positive. Glutamate aminotransferase and other liver function changes are not significant. Patients tend to die within a short period of time. What are the screening methods for serum alkaline phosphatase that may show progressive increase? 1, colorimetric method alkaline phosphatase in alkaline conditions to hydrolyze sodium benzodiphosphate to produce phosphate and free phenol, the latter with 4-aminoantipyrine, and oxidation by potassium ferricyanide to red quinone, the color of its shade is proportional to the alkaline phosphatase activity. 2, continuous monitoring method alkaline phosphatase under alkaline conditions, so that phosphate p-nitrophenol release phosphate group, alkaline phosphatase involved in the transfer of phosphate acyl, promote the enzyme reaction rate, the generation of free p-nitrophenol, and the formation of yellow quinone, the rate of increase in absorbance is proportional to the enzyme activity. Serum alkaline phosphatase is one of the more important indicators of liver function tests and should be brought to the attention of the patient if low serum alkaline phosphatase is present in the liver function test. In general, the normal serum alkaline phosphatase is determined as follows: less than 12 years of age, serum alkaline phosphatase <500 U/L; more than 12 years of age, serum alkaline phosphatase 40-150 U/L. If a patient with a hepatitis B test finds that his serum alkaline phosphatase is lower than the above normal value, this is a case of low serum alkaline phosphatase. Low alkaline phosphatase is usually seen in various obstructive diseases of the liver and bile ducts, such as biliary obstruction caused by bile duct stones, primary biliary cirrhosis, and intrahepatic biliary stasis. For hepatitis cirrhosis only mildly elevated, some patients with jaundice can also cause this condition to occur. Usually low serum alkaline phosphatase occurs due to improper diet and overexertion of the patient. Liver specialists say that low alkaline phosphatase occurs when patients with liver disease do not have a reasonable work and rest schedule and when the liver is diseased. Low serum alkaline phosphatase patients should pay attention to diet, usually do not overwork, and develop a good rest time can generally be recovered. In addition to the scientific diet, it is important to regularly review the condition and keep an eye on the dynamics of the disease.