Epilepsy is known as an “incurable disease” in folklore. The misconceptions of the people and the prejudices of the society make many patients suffer from epilepsy after learning that they are suffering from epilepsy, and the serious psychological burden may aggravate the disease, which will eventually lead to incurable epilepsy. In medicine, what are the factors affecting the cure of epilepsy? 1, organic brain lesions: some epilepsy patients have congenital brain development abnormalities, acquired brain softening lesions, clear epileptogenic lesions such as hippocampal sclerosis, arteriovenous malformations, cavernous hemangiomas, cranial tumors, etc., or part of them are caused by genetic factors, which are the causes of long-term failure to control by drugs. The vast majority of them, instead, can be cured by neurosurgical treatment measures. 2, drug targeting error: because an anti-epileptic drug is not effective for all seizure types, and some anti-epileptic drugs are not only ineffective for a certain seizure type, but can aggravate the seizure, for example, carbamazepine may aggravate akathisia seizures, myoclonic seizures, after the wrong medication, but will aggravate the condition. The patient’s medication dose is insufficient: epilepsy patients in the medication process, the patient’s medication compliance is very important, must be combined by doctors and patients, doctors will grasp the principle of balance between safety and effectiveness according to the condition, slowly feel the specific dosage of each epilepsy patient, with a view to better control seizures. The patient will stop the medication at will: epilepsy medication needs at least 3-5 years, during which the reduction and discontinuation of medication needs to be carried out under the guidance of the doctor and in accordance with the guidelines of the International League Against Epilepsy, many patients feel that they do not have seizures for half a year and stop using medication completely within a few days or stop all medication within a short period of time. This will not only lead to a great risk of having another seizure, but will also cause seizure persistence and directly lead to the prolongation of epilepsy and become refractory to epilepsy.