Irreversible electroporation is a new minimally invasive ablation technique that is gradually moving toward clinical application in recent years. Various ablation techniques, with less trauma and faster recovery, are increasingly concerned and welcomed by doctors and tumor patients in China, but can cause some complications, such as neurovascular damage, damage to bile duct, pancreatic duct, ureter and trachea. Irreversible electroporation technique is to cause apoptosis by irreversible perforation of cell membrane through high voltage electric pulse, which has the advantages of precise ablation, not easy to damage nerve and vascular structure, and no thermal pool effect. Main sites The organs or tissues ablated using irreversible electroporation are mainly liver, lung, breast, pancreas, brain, intestine, narrow blood vessels, etc. The book describes in detail the current parameters, imaging and pathology of tumor treatment at 3 major levels: cytology, animal experiments and clinical studies. Image-guided minimally invasive therapy and bioimmunotherapy are the hot spots and development trends of tumor treatment in the 21st century.