A 24-hour urine protein quantification of more than 150mg indicates positive urine protein, but whether it is serious or not cannot be generalized. The causes of urinary protein are divided into physiological and pathological factors, physiological factors are usually not serious, and pathological causes are usually more serious. However, the 24-hour urine protein quantitative more than 3.5g has reached the standard of nephrotic syndrome, which is usually regarded as serious. 1. Physiological factors: there is no need to worry too much about the transient protein in urine, such as fever, or long time strenuous exercise, such as long-distance running, etc. It is usually not serious, and can be rested for a few days to return to normal. 2. Pathological factors: to combine with other indicators to further analyze the reasons for the increase in urinary protein, when due to primary glomerular lesions, such as acute nephritis, chronic nephritis, etc., after active treatment of urinary protein can be reduced or restored to normal levels. When secondary damage to the kidneys is caused by abnormalities in other systems of the body, such as diabetic nephropathy and other diseases, the condition is usually more serious. If the amount of 24-hour urine protein is abnormal, it is recommended to do further kidney function tests under the guidance of the hospital doctor to make a clear diagnosis, and targeted treatment under the guidance of the doctor.