High C-reactive protein in children usually means that the bacterial infection is more serious, because the C-reactive protein indicator is a response to acute inflammation, pre-surgical tissue damage, surgical trauma, and radiological damage, the value of C-reactive protein will be elevated. C-reactive protein can also be used for the differential diagnosis of bacterial and viral infections, and the cause of elevated C-reactive protein should be analyzed on a case-by-case basis, such as Kawasaki disease, severe tuberculosis, and septic infections. Therefore, an increased C-reactive protein definitely means that there is an abnormal condition and a pathological condition, depending on the specific disease.