There is no such thing as “the best medicine for penis enlargement and thickening”. If the development is not complete, you can take some hormone drugs to improve, if it has been fully developed, can only be improved by surgery. The drugs that can enlarge and thicken the penis mainly include testosterone undecanoate, gonadotropins and other hormone drugs, which can promote penis development to a certain extent, but are mainly used to treat the shortening of the penis caused by the lack of androgen in childhood, which needs to be taken in childhood. If an adult male has a short penis, taking the above drugs will have no therapeutic effect. In this case, penis enlargement and lengthening surgery, is required. If you have a short penis, you can go to the urology department or the male department of the hospital. There are strict indications for the surgery, and you should not blindly implement the surgical treatment.