Pain all over the body when you have a cold and fever is due to the following reasons: a. Cold and fever are usually due to the low immunity of the body when bacteria, viruses, mycoplasma, fungi and other substances will invade the body, and when these pathogenic microorganisms invade the body, they will release inflammatory mediators, including bradykinin, leukotrienes, tumor necrosis factor, prostacyclin and so on, and these substances will lead to nerve root pain and fever These substances will lead to pain and fever in the nerve roots. Second, the body pain when the cold and fever, because at this time the body will consume and release an excess of lactic acid, lactic acid accumulation in the body will also appear all over the body pain, discomfort, so then the patient should be given cold medicine and antipyretic drugs to relieve the situation.