With high estradiol, women may experience symptoms such as irregular vaginal bleeding, breast swelling and pain, uterine fibroids or breast nodules, and men may experience feminizing symptoms. 1. High estradiol in women (1) Irregular vaginal bleeding: female estrogen can make the uterine lining thicken, shed the excessively thick uterine lining, and breakthrough bleeding is manifested as irregular vaginal bleeding, heavy bleeding, and so on. (2) Breast swelling and pain: female estrogen fluctuates and changes during the menstrual cycle. If there is too much estrogen, women may experience breast swelling and pain. (3) Uterine fibroids or breast nodules: Excess estrogen may also stimulate the proliferation of uterine fibroids, which may occur in the long term, and breast nodules in the breast. (2) Increased estrogen in men: androgen is the main hormone in men’s body, if there is too much estrogen, there may be symptoms of feminization such as mammary gland development, thinning of the voice, whiskers, less hair, etc. It may also cause loss of libido, impotence and other conditions.