Metronidazole gel is generally not capable of removing blackheads from the nose. Metronidazole gel belongs to one of the anti-anaerobic drugs, clinically mainly used for inflammatory papules, impetigo, rosacea erythema and other diseases of local treatment, can play a role in hindering bacterial metabolism as well as sterilization. The use of this product occasionally see skin allergic reactions, allergic to the product is prohibited, pregnant and lactating women are prohibited, the use of alcohol during the period of prohibition. Allergies should be used with caution. Blackheads belong to one of the early skin damage of acne, which is mainly related to the increase of sex hormones during pubertal development, the increase of sebum secretion, abnormal keratinization of follicular sebaceous gland ducts, and the large number of propagation of Propionibacterium acnes and other factors. Metronidazole gel does not have the effect of directly treating blackheads. Clinically, blackheads are mainly treated with retinoic acid, benzoyl peroxide, azelaic acid, and other medications that have the effect of improving the keratinization of follicular sebaceous glands, dissolving blackheads, and killing Propionibacterium acnes. The use of the above drugs should follow the doctor’s instructions, if the nose blackheads are more, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor to carry out reasonable treatment.