The world is unpredictable, and accidents always happen unexpectedly, causing such and such injuries to people’s bodies, and craniofacial injury is one of the more serious ones. Once the craniofacial injury occurs, it may be life-threatening to the patient, so timely surgery is necessary, but after surgery, the patient’s life is saved, but in some cases, the skull defect is left behind. Although cranial defect is not fatal, there are many effects of cranial defect, because cranial bone is a defense wall of the brain, which protects the safety of brain tissue. Moreover, the skull shape will become very frightening after cranial defect, and the patient will have a great psychological burden and even depression after a long time. What is the care of skull defect after craniosynostosis surgery? First, psychological care, cranial defect will make patients very insecure, worried and depressed all day long, so it is important to do a good job of psychological care and guidance for patients; second is the care of the affected area, in order to avoid re-injury to the defective parts, patients should pay more attention to the usual time, such as taking a lateral position when sleeping, wearing an elastic matter hat when going out, the intensity of the activity should not be too strong, etc. Of course, in addition to the necessary care work, it is more important to go to the hospital to do the skull repair surgery in time, so as to restore the integrity of the skull as soon as possible and reshape the closed and stable cranial cavity environment to avoid causing more harm to oneself.