When many lymph nodes are palpated in the groin it is usually due to enlargement of the lymph nodes in that area. The common causes are as follows: 1. Localized infections of the lower limbs: for example, infected wounds on the feet or legs, salpingitis, etc. 2. Inflammatory diseases of organs: Inflammatory diseases of the genitourinary system, colon, rectum and other organs can lead to inguinal lymph node enlargement. 3. Systemic diseases: for example, one of the manifestations of lymphoma, chemotherapy should be carried out for lymphoma. 4. HIV infection: corresponding antiviral treatment should be carried out for HIV infection itself. 5. Lymphatic metastasis of malignant tumors: malignant tumors in lower limbs, pelvis and lower abdomen can be metastasized through lymphatic metastasis, resulting in inguinal lymph node enlargement. For example, colorectal cancer, cervical cancer, bone cancer and so on. In conclusion, the causes of swollen inguinal lymph nodes are various, and the medications used for treatment are also various, therefore, when many lymph nodes are felt in the groin, one should go to the hospital in time for diagnosis and treatment.