The most likely cause of a toothache is pulpitis. When pulpitis has an acute attack, it causes severe pain in the tooth, which is spontaneous and radioactive, causing pain throughout the face and even in the skull, and it is difficult to locate the affected tooth. In this case, it is necessary to consult a doctor in a timely manner, and the doctor will check which tooth is suffering from pulpitis, and then do root canal treatment on the corresponding tooth, using anesthetic for local anesthesia, and then remove the infected tooth tissue, open the pulp cavity to inactivate and remove the nerve, after which the pain will be largely relieved or even disappear. If the toothache causes pain on the half side of the face, if it is accompanied by swelling and restricted mouth opening, it means that the wisdom tooth is suffering from pericoronitis, then it is necessary to use sufficient antibiotics to reduce inflammation, you can take oral cephalosporin or metronidazole to reduce inflammation, and if the pain is obvious, you can take oral ibuprofen to relieve pain.