The fever of 39℃ after vaccination is still relatively serious. First of all, observe what discomfort the patient has, and exclude the adverse reaction caused by the vaccination. If it is not caused by the vaccination, it is possible that the fever is 39℃ due to respiratory system infection or digestive system disease, and specific treatment is needed according to the cause. If the fever is 39℃ caused by the vaccination, if the patient is in good spirits and does not appear to be in obvious discomfort, the fever can be reduced first by using antipyretic methods. For example, oral ibuprofen suspension or acetaminophen pellets, the effect of reducing fever is relatively good. For adults, indomethacin suppositories or fever suppositories can be inserted into the patient’s anus to reduce fever, which is also effective. In addition, the use of physical cooling methods can reduce the use of antipyretic drugs, prolong the effect of antipyretic drugs, such as the use of dilute white wine, alcohol to the patient’s skin for bathing. If the temperature does not come down or the patient’s mental state is not good and other uncomfortable symptoms appear, you need to go to the hospital immediately.