Vomiting in late stage of cholangiocarcinoma indicates poor prognosis and the survival time is generally 1~2 months, and the survival time is even shorter if accompanied by jaundice and abdominal pain. Due to factors such as tumor compression of gastrointestinal tract, obstructive jaundice, gastrointestinal reaction and electrolyte disorder, cholangiocarcinoma will lead to nausea and vomiting, which often indicates poor prognosis. Cholangiocarcinoma belongs to digestive system tumors with high malignancy degree, and its overall survival period is short, and the survival period of late stage is generally from half a year to one year. If symptoms such as vomiting, abdominal pain, jaundice, etc. appear in the late stage and there is no timely and effective treatment, the survival time is generally from 1 to 2 months, or even shorter. If patients with advanced stage of cholangiocarcinoma have symptoms such as vomiting, abdominal pain, jaundice, etc., they should take targeted treatment in time, which can improve the quality of life and prolong the survival time of patients appropriately.