High prostate-specific antigen may be related to prostatitis, benign prostatic hyperplasia, and may also be caused by prostate cancer. 1. Prostatitis: it may be related to unclean sex, poor hygiene and other factors, due to the presence of infection, resulting in localized damage to the prostate, which will lead to increased prostate-specific antigen, accompanied by urinary incontinence, frequent urination, urinary urgency, perineal distension and pain and other symptoms. 2. Benign prostatic hyperplasia: it is a common disease in elderly men, which is a benign lesion, leading to a mild increase in prostate-specific antigen, accompanied by frequent urination, difficulty in urination, weakness of urination, and in severe cases, it can cause urinary retention. 3. Prostate cancer: it belongs to malignant lesions, which can lead to the damage of prostate peritoneum, which will lead to the increase of prostate-specific antigen, and may be accompanied by the symptoms of difficulty in urination, blood in the urine, and blood in the semen. If the prostate specific antigen is high and there are abnormal manifestations, it is recommended to do further examination to clarify the specific triggers and timely treatment.