Whether creatinine of 180 μmoI/L is serious depends largely on the cause of its elevation. If it is a physiological reason, or acute kidney injury that causes creatinine elevation, creatinine may return to normal after removing the influencing factors, and it is usually not serious at this time. If the elevated creatinine is caused by chronic kidney disease, with the progress of the disease, it may develop into uremia, which is relatively serious at this time. Normal serum creatinine ranges from 53 to 106 μmol/L in men and from 44 to 97 μmol/L in women. Blood creatinine includes endogenous creatinine and exogenous creatinine. Endogenous creatinine is produced by creatine metabolism and is related to muscle volume and muscle activity; exogenous creatinine is closely related to diet, especially the consumption of heated animal muscle may lead to a rapid increase in blood creatinine levels. Therefore, part of the creatinine elevation may be caused by the patient’s own high muscle content, or usually eat more meat and exercise, if the urine routine and urinary system ultrasound and other related examinations do not see abnormalities, clear kidney without obvious disease, such cases are usually not serious. When the renal parenchyma is damaged and the glomerular filtration rate decreases, the blood creatinine will rise significantly. If the patient has acute kidney injury due to various reasons, creatinine may return to normal after correcting the reversible causes, and this is usually not serious. If chronic kidney disease causes elevated creatinine, with the progress of the disease, it is possible to develop into uremia, which is relatively serious at this time. If patients find that the creatinine is elevated, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.