Direct stimulation of large amounts of alcohol can cause redness and edema of the gastric mucosa, erosion, ulcer formation, and may cause gastrointestinal bleeding and hemorrhoid bleeding; drinking strong alcohol, especially on an empty stomach, can cause edema and obstruction of the duodenal papillae leading to pancreatitis; alcohol in the blood can excite the sympathetic nervous system indirectly causing massive secretion of gastric acid and reflux of bile to aggravate the damage to the gastric mucosa; vomiting after drinking large amounts of alcohol can cause pancreatic mucosa The vomiting after drinking a lot of alcohol can cause bleeding of pancreatic mucosa lacerations. Therefore, it is not recommended to drink large amounts of strong alcohol or alcohol on an empty stomach, especially for people with epigastric fasting pain, nocturnal pain, acid reflux, and noisy symptoms; people with a clear history of erosive gastritis, gastroduodenal ulcer disease, and reflux esophagitis should not drink alcohol as much as possible; endoscopic EMR of gastrointestinal polyps and mucosal lesions should be controlled within one month after ESD treatment; for a person who never drinks alcohol, it is even more important not to For a person who has never drunk alcohol should not drink a large amount of alcohol at one time or passively persuaded to drink alcohol because of the lack of strong protective effect of prostaglandins. The gastrointestinal tract is protected by moderate drinking of alcohol every day to stimulate the production of prostaglandins in the gastrointestinal mucosa, which can improve the resistance and adaptability of the gastrointestinal tract to external stimuli, so that a little more wine by chance at a friend’s party will not be a big deal; moderate drinking of alcohol can promote the secretion of digestive juices such as gastric juice, intestinal juice and pancreatic juice, to enhance appetite, appetite and digestion. Therefore, for people with symptoms such as postprandial fullness, loss of appetite, early satiety and anorexia in the upper and middle abdomen, and for friends diagnosed with superficial gastritis, mild to moderate atrophic gastritis and other indigestion, it is beneficial to drink a moderate amount of wine every day and drink a small amount of wine while eating.